Reduction in hypericin-induced phototoxicity by Hypericum perforatum extracts and pure compounds
نویسندگان
چکیده
منابع مشابه
Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds.
Hypericum perforatum (Hp) is known for possessing antidepressant and antiviral activities. Despite its use as an alternative to conventional antidepressants, the identification of the cytotoxic chemicals derived from this herb is incomplete. In this study, the cytotoxicity of Hp extracts prepared in solvents ranging in polarity, fractions of one extract, and purified compounds were examined in ...
متن کاملHypericin Extracts Antibacterial Effect of Cultivated Hypericum perforatum Against Staphylococcus aureus Susceptible and Methicillin-Resistant
Staphylococcus aureus are important factors for infections that acquired of hospital and community. Infections caused by methicillin-resistant Staphylococcus aureus mainly of hospital origin, which in many countries is increasing. For this reason, many researchers have tried to find new compounds as a substitute for these antibiotics. Hypericin is the active substance H.perforatum and licone ma...
متن کاملPhytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts
The antioxidant potentials of a total ethanolic extract of Hypericum perforatum (TE) and fractions were evaluated and correlated with their phenolic contents. The extracts were fully characterised by HPLC–DAD–MS–MS. Kaempferol 3-rutinoside and rutinacetyl were identified for the first time in TE extracts. The free radical-scavenging properties of TE (EC50 1⁄4 21 lg dwb/ml) and fractions were st...
متن کاملJ Turk Acad Dermatol 2014; 8 (2): 1482c5
Observations: Hypericin, originating from Hypericum perforatum, is a potent photosensitizer known to induce skin phototoxicity when given systemically. Hypericum perforatum is a botanical extracts with anti-inflammatory and antibacterial effect. Photocontact dermatitis is a common cutaneous reaction by various herbs. We describe a 54-year-old female patient with Hypericum perforatum associated ...
متن کاملAntioxidant activity relationship of phenolic compounds in Hypericum perforatum L.
BACKGROUND The St John's Wort (Hypericum perforatum; Clusiaceae) has been used in traditional and modern medicine for a long time due to its high content of biologically active phenolics. The purpose of this work was to develop a method for their fractionation and identification, and to determine the most active antioxidant compounds in plant extract. RESULTS An LC-MS method which enables fas...
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ژورنال
عنوان ژورنال: Journal of Photochemistry and Photobiology B: Biology
سال: 2006
ISSN: 1011-1344
DOI: 10.1016/j.jphotobiol.2006.06.001